Nuclear Reprogramming in Cells
نویسندگان
چکیده
منابع مشابه
Nuclear reprogramming in cells.
Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type. Early studies in frog cloning provided some of the first experimental evidence for reprogramming. Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming. Through these ...
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Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...
متن کاملStem Cells and Nuclear Reprogramming
1Renova Life Inc., University of Maryland, College Park, MD 20742, USA 2Center for Regenerative Biology, University of Connecticut, Storrs, CT 06269, USA 3Consorzio di Ricerca e Sperimentazione per gli Allevatori (CRSA), 00161 Rome, Italy 4Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan 5Department of Animal Science, National Pingtung University of Sc...
متن کاملEndothelial cells derived from nuclear reprogramming.
The endothelium plays a pivotal role in vascular homeostasis, regulating the tone of the vascular wall, and its interaction with circulating blood elements. Alterations in endothelial functions facilitate the infiltration of inflammatory cells and permit vascular smooth muscle proliferation and platelet aggregation. Therefore, endothelial dysfunction is an early event in disease processes inclu...
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Embryonic stem cells have two unique properties. They are capable of indefinite self-renewal and, being pluripotent, they can differentiate into all possible cell types, including germ cells. A new study by Cowan et al. (2005) published in Science shows that human embryonic stem cells are able to reprogram the nuclei of fully differentiated human somatic cells, apparently conferring on them a p...
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ژورنال
عنوان ژورنال: Science
سال: 2008
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1160810